Cetaphil
Advanced Daily Defense SerumA serum built around Niacinamide and Vitamin E, for hydration and pollution defence.
A serum built around Niacinamide and Zinc salt, for hydration and barrier repair.
Brand price
Not recorded · brand's site
Brand price
USD 25.00 · checked 25 Sept 2026 · brand's site

At a Glance

Every check both products could be assessed on comes out the same. Tap any answer to see why.

Key Ingredients

Hyaluronic acid1
Hyaluronic acid and its salts; a humectant that binds water to the skin.

Benefits

Hydrating5
Boosts hydration and relieves dry, tight skin.
Butylene Glycol, Hydrolyzed Hyaluronic Acid, Peg/Ppg-8/3 Laurate, Sodium Hyaluronate, Tocopherol
Barrier Repair3
Strengthens and restores the skin's natural barrier.
Hydrating5
Boosts hydration and relieves dry, tight skin.
Acetyl Glucosamine, Butylene Glycol, Tocopherol, Trehalose, Zinc PCA
Barrier Repair3
Strengthens and restores the skin's natural barrier.

Concerns

May Worsen Seborrheic Dermatitis1
May feed the yeast involved in seborrheic dermatitis.
May Worsen Seborrheic Dermatitis1
May feed the yeast involved in seborrheic dermatitis.

Ingredients Side-by-side

Water (in both products)
Skin Conditioning
Humectant
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Emulsifying
1,2-Hexanediol (in both products)
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Epigallocatechin Gallatyl Glucoside
Antioxidant
Humectant
Water (in both products)
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Skin Conditioning
- Fatty alcohols (Malassezia)
- Dark Spots
- Hydrating
- May Worsen Seborrheic Dermatitis
1,2-Hexanediol (in both products)
Skin Conditioning
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water
Antiplaque, Skin Conditioning, Solvent
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
Learn more about Water →Butylene Glycol
Fragrance, Humectant, Skin Conditioning, Solvent, Viscosity Controlling
Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)
Learn more about Butylene Glycol →Pentylene Glycol
Skin Conditioning, Solvent
1,2-Dihydroxypentane
Learn more about Pentylene Glycol →1,2-Hexanediol
Skin Conditioning, Solvent
We don't have a description for 1,2-Hexanediol yet.
Learn more about 1,2-Hexanediol →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Allantoin
Skin Conditioning, Skin Protecting, Soothing
Urea, (2,5-dioxo-4-imidazolidinyl)-
Learn more about Allantoin →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →Citric Acid
Buffering, Chelating, Fragrance
Citric Acid is an AHA.
Learn more about Citric Acid →
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