Differin Adapalene Gel 0.3% vs Clinique Acne Solutions™ All-Over Clearing Treatment

Differin

Clinique

An acne treatment built around Adapalene, for hydration and barrier repair.

An acne treatment built around Vitamin E, for barrier repair and smoothing.

Acne treatment

9 ingredients

41 ingredients

Brand price

Not recorded

Brand price

USD 31.00 · checked 8 Oct 2026 · brand's site

No retailer listed yet

At a Glance

They come out differently on Paraben-free, Silicone-free, Fungal-acne-safe and Oil-free; those rows are shaded. Tap any answer to see why.

Adapalene1
A third-generation retinoid, sold over the counter for acne.
Adapalene

Mineral sunscreen1
Uses zinc oxide or titanium dioxide to absorb and scatter UV rays.
Titanium Dioxide
Sunscreen1
Any ingredient acting as a UV filter.
Titanium Dioxide
Vitamin E1
Tocopherols — fat-soluble antioxidants.
Tocopheryl Acetate
Polysorbates (Tween emulsifiers)1
Polysorbate (Tween) emulsifiers.
Polysorbate 80

Hydrating1
Boosts hydration and relieves dry, tight skin.
Propylene Glycol
Barrier Repair1
Strengthens and restores the skin's natural barrier.
Propylene Glycol
Smoothing1
Refines rough or uneven texture.
Adapalene
Acne Fighting1
Helps clear breakouts and keep pores clear.
Adapalene

No concerns found

May Trigger Acne2
Can clog pores or trigger breakouts.
Ceteareth-20, Myristyl Alcohol
May Worsen Seborrheic Dermatitis6
May feed the yeast involved in seborrheic dermatitis.
Acetyl Glucosamine, Astrocaryum Murumuru Seed Butter, Ceteareth-20, Linoleic Acid, Myristyl Alcohol, Polysorbate 80
May Worsen Keratosis Pilaris2
May clog follicles or strip skin prone to keratosis pilaris.
Ceteareth-20, Myristyl Alcohol
May Worsen Oily Skin1
May increase shine or excess oil.
Astrocaryum Murumuru Seed Butter

Show highlights for:

Aqua
Solvent
0 / —
Cyclopentasiloxane
Emollient
0-1 / —
- Silicones
Butylene Glycol
Humectant
1 / 0
- Hydrating
Cyclohexasiloxane
Emollient
0-1 / —
- Silicones
Ceteareth-20
Cleansing
2 / 3
- Fatty alcohols (Malassezia)
- May Trigger Acne
- May Worsen Irritation
- May Worsen Keratosis Pilaris
- May Worsen Seborrheic Dermatitis
Dimethicone
Emollient
1 / 0
- Silicones
- Barrier Repair
- Hydrating
- Smoothing
Sucrose
Humectant
0-1 / —
Camellia Sinensis Leaf Extract
Emollient
- Anti-Pollution
- Antioxidant
- Reduces Irritation
Hordeum Vulgare Extract
Emollient
Acetyl Glucosamine
Skin Conditioning
- Fatty alcohols (Malassezia)
- Dark Spots
- Hydrating
- May Worsen Seborrheic Dermatitis

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Disodium EDTA
Chelating, Viscosity Controlling
Disodium dihydrogen ethylenediaminetetraacetate
Learn more about Disodium EDTA →

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