Differin Epiduo vs Paula's Choice Acne Body Spray

Differin

Paula's Choice

An acne treatment built around Adapalene and Benzoyl peroxide, for barrier repair and hydration.

An acne treatment built around BHA and Salicylic acid, for hydration and barrier repair.

Acne treatment

12 ingredients

21 ingredients

Brand price

Not recorded

Brand price

USD 30.00 · checked 8 Oct 2026 · brand's site

No retailer listed yet

At a Glance

They come out differently on Cruelty-free; that row is shaded. Tap any answer to see why.

Polysorbates (Tween emulsifiers)1
Polysorbate (Tween) emulsifiers.
Polysorbate 80
Adapalene1
A third-generation retinoid, sold over the counter for acne.
Adapalene
Benzoyl peroxide1
An antibacterial acne treatment that kills C. acnes.
Benzoyl Peroxide

Panthenol (provitamin B5)1
Provitamin B5 — a humectant and soother.
Panthenol
Polysorbates (Tween emulsifiers)1
Polysorbate (Tween) emulsifiers.
Polysorbate 20
BHA1
Beta hydroxy acid — oil-soluble, so it works inside the pore.
Salicylic Acid
Salicylic acid1
The BHA used in acne treatment.
Salicylic Acid

Hydrating2
Boosts hydration and relieves dry, tight skin.
Glycerin, Propylene Glycol
Barrier Repair3
Strengthens and restores the skin's natural barrier.
Glycerin, Isohexadecane, Propylene Glycol
Smoothing2
Refines rough or uneven texture.
Adapalene, Isohexadecane
Acne Fighting2
Helps clear breakouts and keep pores clear.
Adapalene, Benzoyl Peroxide

Hydrating7
Boosts hydration and relieves dry, tight skin.
Butylene Glycol, Dipotassium Glycyrrhizate, Glycereth-26, Glycerin, Methyl Gluceth-20, Panthenol, Sodium Hyaluronate
Barrier Repair4
Strengthens and restores the skin's natural barrier.
Allantoin, Glycerin, Glycyrrhiza Glabra Root Extract, Panthenol
Reduces Irritation4
Eases discomfort and supports skin resilience.
Allantoin, Dipotassium Glycyrrhizate, Glycyrrhiza Glabra Root Extract, Panthenol
Redness Reducing2
Soothes visible redness and calms irritation.
Allantoin, Glycyrrhiza Glabra Root Extract

May Trigger Acne1
Can clog pores or trigger breakouts.
Sorbitan Oleate
May Worsen Seborrheic Dermatitis2
May feed the yeast involved in seborrheic dermatitis.
Polysorbate 80, Sorbitan Oleate
May Worsen Keratosis Pilaris1
May clog follicles or strip skin prone to keratosis pilaris.
Sorbitan Oleate

May Trigger Acne1
Can clog pores or trigger breakouts.
Lauric Acid
May Worsen Seborrheic Dermatitis2
May feed the yeast involved in seborrheic dermatitis.
Lauric Acid, Polysorbate 20
May Worsen Keratosis Pilaris1
May clog follicles or strip skin prone to keratosis pilaris.
Lauric Acid

Show highlights for:

Adapalene
- Adapalene
- Acne Fighting
- Smoothing
Benzoyl Peroxide
Oxidising
0 / —
- Benzoyl peroxide
- Acne Fighting
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion Stabilising
Diethylhexyl Sodium Sulfosuccinate
Cleansing
Disodium EDTA (in both products)
Chelating
0 / —
Glycerin (in both products)
Humectant
0 / 0
- Possibly animal-derived
- Hydrating
Isohexadecane
Emollient
Poloxamer 124
Cleansing
Polysorbate 80
Cleansing
0 / 0
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- Polysorbates (Tween emulsifiers)
- May Worsen Seborrheic Dermatitis
Propylene Glycol
Humectant
0 / 0

Water (in both products)
Skin Conditioning
Dipropylene Glycol
Perfuming
0-1 / —
Butylene Glycol
Humectant
1 / 0
- Hydrating
Polysorbate 20
Cleansing
0 / 0
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- Polysorbates (Tween emulsifiers)
- May Worsen Seborrheic Dermatitis
Pentylene Glycol
Skin Conditioning
0-1 / —
Salicylic Acid
Preservative
- BHA
- Salicylic acid
- Acne Fighting
- Exfoliating
- Oil Control
- Pore Refining
Panthenol
Skin Conditioning
0 / 0
- Panthenol (provitamin B5)
- Barrier Repair
- Hydrating
- Reduces Irritation
Sodium Hyaluronate
Humectant
0 / 0
- Hyaluronic acid
- Hydrating
Dipotassium Glycyrrhizate
Humectant
- Brightening
- Reduces Irritation
Glycyrrhiza Glabra Root Extract
Emollient
- Brightening
- Redness Reducing
- Reduces Irritation

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Disodium EDTA
Chelating, Viscosity Controlling
Disodium dihydrogen ethylenediaminetetraacetate
Learn more about Disodium EDTA →
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →
Water
Antiplaque, Skin Conditioning, Solvent
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
Learn more about Water →