SkinCeuticals
Discoloration Defense Serum for Dark SpotsIsntree
Onion Newpair Ampoule PlusA serum built around Niacinamide and Tranexamic acid, for barrier repair and hydration.
A serum built around Niacinamide and Hyaluronic acid, for hydration and barrier repair.
Brand price
USD 115.00 · checked 28 Sept 2026 · brand's site
Brand price
Not recorded · brand's site
Buy at
Retailer links are affiliate links. Buying through one may earn us a commission at no cost to you.

At a Glance

They come out differently on Fungal-acne-safe and Cruelty-free; those rows are shaded. Tap any answer to see why.

Key Ingredients

Hyaluronic acid1
Hyaluronic acid and its salts; a humectant that binds water to the skin.

Benefits

Hydrating4
Boosts hydration and relieves dry, tight skin.
Butylene Glycol, Glycerin, Hydroxyethyl Urea, Propylene Glycol
Barrier Repair5
Strengthens and restores the skin's natural barrier.
Allantoin, Caprylyl Glycol, Glycerin, Niacinamide, Propylene Glycol
Redness Reducing3
Soothes visible redness and calms irritation.
Hydrating11
Boosts hydration and relieves dry, tight skin.
Acetyl Glucosamine, Betaine, Butylene Glycol, Glycerin, Hydrolyzed Hyaluronic Acid, Panthenol, Propanediol, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Squalane, Trehalose
Barrier Repair7
Strengthens and restores the skin's natural barrier.
Allantoin, Betaine, Caprylyl Glycol, Glycerin, Niacinamide, Panthenol, Squalane
Redness Reducing3
Soothes visible redness and calms irritation.

Concerns

No concerns found
May Worsen Seborrheic Dermatitis5
May feed the yeast involved in seborrheic dermatitis.
Acetyl Glucosamine, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Hydrogenated Lecithin, Polyglyceryl-10 Laurate, Sodium Acetylated Hyaluronate

Ingredients Side-by-side

Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Tranexamic Acid (in both products)
Skin Conditioning
- Tranexamic acid
- Brightening
- Dark Spots
- Even Tone
- Redness Reducing
Humectant
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Skin Conditioning
Antioxidant
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol
Fragrance, Humectant, Skin Conditioning, Solvent, Viscosity Controlling
Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)
Learn more about Butylene Glycol →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Tranexamic Acid
Astringent, Skin Conditioning
Tranexamic Acid is tranexamic acid.
Learn more about Tranexamic Acid →Caprylyl Glycol
Deodorant, Hair Conditioning, Skin Conditioning, Emollient
Caprylyl Glycol is the diol that conforms to the formula
Learn more about Caprylyl Glycol →Allantoin
Skin Conditioning, Skin Protecting, Soothing
Urea, (2,5-dioxo-4-imidazolidinyl)-
Learn more about Allantoin →Disodium EDTA
Chelating, Viscosity Controlling
Disodium dihydrogen ethylenediaminetetraacetate
Learn more about Disodium EDTA →
Similar Comparisons
Each product against its closest dupes.
- View the comparison

SkinCeuticals
Discoloration Defense Serum for Dark Spots

Glad2Glow
Pdrn 10% Niacinamide 3% Txa Brightening Serum
- View the comparison

Isntree
Onion Newpair Ampoule Plus

Medicube
TXA Niacinamide Serum
- View the comparison

SkinCeuticals
Discoloration Defense Serum for Dark Spots

The Derma Co
Tran-Zelaic Pigmentation Corrector Serum with Tranexamic Acid & Azelaic Acid
- View the comparison

Isntree
Onion Newpair Ampoule Plus

VT Cosmetics
Hydrop reedle shot 100