Advanced Daily Defense Serum
10% Niacinamide Booster

Cetaphil

Advanced Daily Defense Serum

Paula's Choice

10% Niacinamide Booster

A serum built around Niacinamide and Vitamin E, for hydration and pollution defence.

A serum built around Niacinamide and Vitamin C derivative, for hydration and barrier repair.

Serum
Serum
16 ingredients
27 ingredients

Brand price

Not recorded · brand's site

Brand price

USD 53.00 · checked 8 Oct 2026 · brand's site

No retailer listed yet
No retailer listed yet
Brand from United States
Brand country not recorded

At a Glance

They come out differently on Pore-clogger-free, Vegan and Cruelty-free; those rows are shaded. Tap any answer to see why.

Key Ingredients

  • Vitamin C derivative (stable)1

    Stable derivatives of ascorbic acid.

    Ascorbyl Glucoside

  • Panthenol (provitamin B5)1

    Provitamin B5 — a humectant and soother.

    Panthenol

  • Polysorbates (Tween emulsifiers)1

    Polysorbate (Tween) emulsifiers.

    Polysorbate 20

  • AHA1

    Alpha hydroxy acids — water-soluble chemical exfoliants.

    Citric Acid

Benefits

Concerns

  • May Trigger Acne1

    Can clog pores or trigger breakouts.

    Tocopherol

  • May Worsen Seborrheic Dermatitis1

    May feed the yeast involved in seborrheic dermatitis.

    Peg/Ppg-8/3 Laurate

  • May Worsen Keratosis Pilaris1

    May clog follicles or strip skin prone to keratosis pilaris.

    Tocopherol

  • May Worsen Irritation1

    May cause stinging, redness or sensitivity.

    Tocopherol

Ingredients Side-by-side

Show highlights for:

  • Water (in both products)

    Skin Conditioning

  • Niacinamide (in both products)

    Smoothing

    0 / —

    • Niacinamide
    • Acne Fighting
    • Barrier Repair
    • Brightening
    • Dark Spots
    • Even Tone
    • Oil Control
    • Pore Refining
    • Redness Reducing

  • Acetyl Glucosamine

    Skin Conditioning

    • Fatty alcohols (Malassezia)
    • Dark Spots
    • Hydrating
    • May Worsen Seborrheic Dermatitis

  • Ascorbyl Glucoside

    Antioxidant

    • Vitamin C
    • Vitamin C derivative (stable)
    • Antioxidant
    • Brightening
    • Dark Spots

  • Butylene Glycol (in both products)

    Humectant

    1 / 0

    • Hydrating

  • Phospholipids

    Skin Conditioning

    • Fatty esters (glyceryl stearate, PEG-100 stearate)
    • May Worsen Seborrheic Dermatitis

  • Sodium Hyaluronate (in both products)

    Humectant

    0 / 0

    • Hyaluronic acid
    • Hydrating

  • Allantoin (in both products)

    Skin Conditioning

    0 / 0

    • Reduces Irritation
    • Smoothing

  • Boerhavia Diffusa Root Extract

    Skin Protecting

  • Glycerin

    Humectant

    0 / 0

    • Possibly animal-derived
    • Hydrating

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Similar Comparisons

Each product against its closest dupes.