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Medicube
Azelaic Acid 16 Calming Serum
A serum built around Azelaic acid and Niacinamide, for barrier repair and smoothing.
Brand price
USD 26.00 · checked 26 Sept 2026 · on the brand's site
From the brand
What the brand says about this product. Our ingredient analysis follows below.
The brand recommends it for
- Combination skin
- Sensitive skin
- Dark spots & pigmentation
How to use
After applying toner, apply a few drops and gently spread it following the skin's texture. And lightly pat it in for absorption.
Caution
Notice Due to the nature of high-concentration Azelaic Acid, slight residue or layering may appear. For better absorption, apply a thin layer at a time and allow it to fully absorb before applying more.
What's inside
Ingredients List
5 trigger at least one check · 26 trigger none
- Denatured alcohol
- May Worsen Dryness
- May Worsen Eczema
- May Worsen Irritation
- May Worsen Rosacea
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Key Ingredients
Centella asiatica (Cica)1
Centella asiatica (cica), used to calm irritation.
Benefits
Hydrating7
Boosts hydration and relieves dry, tight skin.
Butylene Glycol, Butyrospermum Parkii Butter, Ceramide NP, Panthenol, Propanediol, Propylene Glycol, Squalane
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Allantoin, Aloe Barbadensis Flower Extract, Butyrospermum Parkii Butter, Centella Asiatica Extract, Ceramide NP, Glyceryl Caprylate, Hydrolyzed Pea Protein, Lecithin, Niacinamide, Olea Europaea Fruit Oil, Panthenol, Propylene Glycol, Squalane
Reduces Irritation3
Eases discomfort and supports skin resilience.
Redness Reducing4
Soothes visible redness and calms irritation.
Allantoin, Azelaic Acid, Centella Asiatica Extract, Niacinamide
Smoothing9
Refines rough or uneven texture.
Allantoin, Aloe Barbadensis Flower Extract, Centella Asiatica Extract, Citric Acid, Glyceryl Caprylate, Hydrolyzed Pea Protein, Lecithin, Niacinamide, Squalane
Concerns
May Worsen Seborrheic Dermatitis4
May feed the yeast involved in seborrheic dermatitis.
Butyrospermum Parkii Butter, Ceramide NP, Lecithin, Olea Europaea Fruit Oil
May Worsen Keratosis Pilaris1
May clog follicles or strip skin prone to keratosis pilaris.
May Worsen Oily Skin3
May increase shine or excess oil.
Butyrospermum Parkii Butter, Olea Europaea Fruit Oil, Squalane
Ingredients Explained
Click on any ingredient to learn more about it
Water
Antiplaque, Skin Conditioning, Solvent
Aqua (EU),Deionized Water,Distilled Water,Micromatrix Fractile AN,Onsen-Sui (JPN),Purified Water
Learn more about Water →Azelaic Acid
Buffering, Fragrance
Azelaic Acid is azelaic acid.
Learn more about Azelaic Acid →Butylene Glycol
Fragrance, Humectant, Skin Conditioning, Solvent, Viscosity Controlling
Butane-1,3-diol (CAS No. 107-88-0/ EC No. 203-529-7) (R)-(-)-butane-1,3-diol” (CAS No. 6290-03-5/ EC No. 228-532-0)
Learn more about Butylene Glycol →Propanediol
Solvent, Viscosity Controlling
Propanediol is the organic compound that conforms to the formula
Learn more about Propanediol →Sodium Hydroxide
Buffering, Denaturant
Sodium hydroxide
Learn more about Sodium Hydroxide →Propylene Glycol
Fragrance, Humectant, Humectant, Skin Conditioning, Solvent, Viscosity Controlling
Propylene Glycol is the aliphatic alcohol that conforms generally to the formula
Learn more about Propylene Glycol →Alcohol Denat.
Antifoaming, Antimicrobial, Astringent, Fragrance, Solvent, Viscosity Controlling
Alcohol Denat. is a drying alcohol.
Learn more about Alcohol Denat. →1,2-Hexanediol
Skin Conditioning, Solvent
We don't have a description for 1,2-Hexanediol yet.
Learn more about 1,2-Hexanediol →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Citric Acid
Buffering, Chelating, Fragrance
Citric Acid is an AHA.
Learn more about Citric Acid →
Dupes
- Medicube Azelaic Acid Exosome Shot72% match
- Anua Azelaic Acid 10 Hyaluron Redness Soothing Serum70% match
- Skin1004 Hyalu-Cica First Ampoule70% match
- Numbuzin No.1 Pantothenic B5 Active Soothing Serum70% match
- Medicube Kojic Acid Turmeric Capsule Serum69% match
- Numbuzin No.6 Deep Sleep Mask Serum69% match