SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide and Tranexamic acid, for barrier repair and hydration.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 25.65 · checked 26 Sept 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
At a Glance
Every check both products could be assessed on comes out the same. Tap any answer to see why.
Key Ingredients
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Ceramide3
Skin-identical lipids that hold the barrier together.
Vitamin C (L-ascorbic acid)1
L-ascorbic acid, the unesterified form of vitamin C.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating14
Boosts hydration and relieves dry, tight skin.
Beta-Glucan, Betaine, Butylene Glycol, Caprylic/Capric Triglyceride, Ceramide AP, Ceramide EOP, Ceramide NP, Dimethiconol, Fructooligosaccharides, Glycerin, Hydrolyzed Hyaluronic Acid, Phenyl Trimethicone, Propanediol, Tocopherol
Barrier Repair20
Strengthens and restores the skin's natural barrier.
Behenyl Alcohol, Betaine, Caprylic/Capric Triglyceride, Ceramide AP, Ceramide EOP, Ceramide NP, Cetearyl Alcohol, Cetearyl Olivate, Cholesterol, Dicaprylyl Ether, Dimethiconol, Eriobotrya Japonica Leaf Extract, Glycerin, Glyceryl Stearate, Hydrogenated Poly(C6-14 Olefin), Laminaria Japonica Extract, Macadamia Integrifolia Seed Oil, Niacinamide, Phenyl Trimethicone, Tocopherol
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne3
Can clog pores or trigger breakouts.
May Worsen Seborrheic Dermatitis14
May feed the yeast involved in seborrheic dermatitis.
Behenyl Alcohol, Ceramide AP, Ceramide As, Ceramide EOP, Ceramide NP, Ceramide Ns, Cetearyl Alcohol, Cetearyl Glucoside, Cetearyl Olivate, Glyceryl Stearate, Glyceryl Stearate Se, Hydrogenated Lecithin, Macadamia Integrifolia Seed Oil, Sorbitan Olivate
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Skin Conditioning
Macadamia Integrifolia Seed Oil
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Hydrogenated Poly(C6-14 Olefin)
Emollient
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Xanthan Gum
Binding, Emulsion Stabilising, Gel Forming, Skin Conditioning, Cleansing, Emulsifying, Viscosity Controlling
Xanthan gum
Learn more about Xanthan Gum →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →
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