SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide, for barrier repair and hydration.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 23.40 · checked 26 Sept 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
At a Glance
They come out differently on Fragrance-free; that row is shaded. Tap any answer to see why.
Key Ingredients
Fatty alcohol2
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Centella asiatica (Cica)1
Centella asiatica (cica), used to calm irritation.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating13
Boosts hydration and relieves dry, tight skin.
Beta-Glucan, Butylene Glycol, Butyrospermum Parkii Butter, Ceramide NP, Dimethicone, Fructooligosaccharides, Glycerin, Hydrolyzed Hyaluronic Acid, Propanediol, Sodium Hyaluronate, Stearic Acid, Tocopherol, Trehalose
Barrier Repair17
Strengthens and restores the skin's natural barrier.
Acmella Oleracea Extract, Behenyl Alcohol, Butyrospermum Parkii Butter, Centella Asiatica Extract, Ceramide NP, Cetearyl Alcohol, Cetyl Alcohol, Cholesterol, Dimethicone, Glycerin, Laminaria Japonica Extract, Malt Extract, Neopentyl Glycol Diheptanoate, Niacinamide, Palmitic Acid, Stearic Acid, Tocopherol
Reduces Irritation2
Eases discomfort and supports skin resilience.
Redness Reducing2
Soothes visible redness and calms irritation.
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne7
Can clog pores or trigger breakouts.
Cetearyl Alcohol, Cetyl Alcohol, Glyceryl Stearate Se, Myristic Acid, Palmitic Acid, Stearic Acid, Tocopherol
May Worsen Seborrheic Dermatitis14
May feed the yeast involved in seborrheic dermatitis.
Behenyl Alcohol, Butyrospermum Parkii Butter, Ceramide NP, Cetearyl Alcohol, Cetyl Alcohol, Glyceryl Stearate Se, Hydrogenated Lecithin, Morinda Citrifolia Seed Oil, Myristic Acid, Palmitic Acid, Polyglyceryl-10 Myristate, Polyglyceryl-3 Methylglucose Distearate, Sodium Stearoyl Glutamate, Stearic Acid
May Worsen Keratosis Pilaris7
May clog follicles or strip skin prone to keratosis pilaris.
Cetearyl Alcohol, Cetyl Alcohol, Glyceryl Stearate Se, Myristic Acid, Palmitic Acid, Stearic Acid, Tocopherol
May Worsen Oily Skin2
May increase shine or excess oil.
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Morinda Citrifolia Fruit Extract
Skin Conditioning
Skin Conditioning
Hydrogenated Poly
Emollient
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Butyrospermum Parkii Butter (in both products)
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Butyrospermum Parkii Butter (in both products)
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Butyrospermum Parkii Butter
Skin Conditioning, Viscosity Controlling
Butyrospermum Parkii Butter isn't fungal acne safe.
Learn more about Butyrospermum Parkii Butter →Dimethicone
Antifoaming, Skin Conditioning, Emollient, Skin Protecting
Dimethicone is a silicone.
Learn more about Dimethicone →Cetyl Alcohol
Emulsion Stabilising, Fragrance, Opacifying, Emollient, Cleansing, Emulsifying, Foam Boosting, Viscosity Controlling
Cetyl Alcohol isn't fungal acne safe.
Learn more about Cetyl Alcohol →Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Palmitic Acid
Emollient, Emulsifying
Palmitic Acid may be plant, synthetic or animal depending on the supplier.
Learn more about Palmitic Acid →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →
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