Clinique Dramatically Different™ Moisturizing Cream vs SkinCeuticals Advanced RGN-6

Clinique

SkinCeuticals

A face cream built around Hyaluronic acid, for barrier repair and smoothing.

A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.

Face cream

25 ingredients

29 ingredients

Brand price

USD 34.00 · checked 8 Oct 2026 · brand's site

Brand price

USD 195.00 · checked 28 Sept 2026 · brand's site

No retailer listed yet

At a Glance

They come out differently on Pore-clogger-free; that row is shaded. Tap any answer to see why.

Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Cetyl Alcohol
Hyaluronic acid1
Hyaluronic acid and its salts; a humectant that binds water to the skin.
Sodium Hyaluronate

Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Cetyl Alcohol
Face oil1
An oil formulated to be used on the face.
Squalane
Vitamin E1
Tocopherols — fat-soluble antioxidants.
Tocopherol
AHA1
Alpha hydroxy acids — water-soluble chemical exfoliants.
Citric Acid

May Trigger Acne1
Can clog pores or trigger breakouts.
Cetyl Alcohol
May Worsen Seborrheic Dermatitis7
May feed the yeast involved in seborrheic dermatitis.
Behenyl Alcohol, Cetyl Alcohol, PEG-100 Stearate, Polyglyceryl-10 Pentastearate, Sodium Stearoyl Lactylate, Tridecyl Stearate, Tridecyl Trimellitate
May Worsen Keratosis Pilaris1
May clog follicles or strip skin prone to keratosis pilaris.
Cetyl Alcohol
May Worsen Oily Skin1
May increase shine or excess oil.
Petrolatum

May Trigger Acne3
Can clog pores or trigger breakouts.
Cetyl Alcohol, Palmitic Acid, Tocopherol
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Cetyl Alcohol, Palmitic Acid, Tocopherol
May Worsen Oily Skin2
May increase shine or excess oil.
Butyrospermum Parkii Butter, Squalane

Show highlights for:

Aqua (in both products)
Solvent
0 / —
Glycerin (in both products)
Humectant
0 / 0
- Possibly animal-derived
- Hydrating
Dimethicone (in both products)
Emollient
1 / 0
- Silicones
- Barrier Repair
- Hydrating
- Smoothing
Petrolatum
Emollient
0 / —
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
Tridecyl Stearate
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Tridecyl Trimellitate
Emollient
- Fatty alcohols (Malassezia)
- May Worsen Seborrheic Dermatitis
Polyglyceryl-10 Pentastearate
Skin Conditioning
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Behenyl Alcohol
Emollient
- Fatty alcohols (Malassezia)
- May Worsen Seborrheic Dermatitis
PEG-100 Stearate
Cleansing
0 / 0
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Cetyl Alcohol (in both products)
Emollient
2 / 2
- Fatty alcohol
- Fatty alcohols (Malassezia)
- May Trigger Acne
- May Worsen Irritation
- May Worsen Keratosis Pilaris
- May Worsen Seborrheic Dermatitis

Aqua (in both products)
Solvent
0 / —
Glycerin (in both products)
Humectant
0 / 0
- Possibly animal-derived
- Hydrating
Ethyl Oleate
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Squalane
Emollient
1 / 0
- Face oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
C12-16 Alcohols
Emollient
- Fatty alcohols (Malassezia)
- May Worsen Seborrheic Dermatitis
Glyceryl Stearate Citrate
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Butyrospermum Parkii Butter
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Maltodextrin
Skin Conditioning
0-1 / —
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Aqua
Solvent
Water
Learn more about Aqua →
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →
Dimethicone
Antifoaming, Skin Conditioning, Emollient, Skin Protecting
Dimethicone is a silicone.
Learn more about Dimethicone →
Cetyl Alcohol
Emulsion Stabilising, Fragrance, Opacifying, Emollient, Cleansing, Emulsifying, Foam Boosting, Viscosity Controlling
Cetyl Alcohol isn't fungal acne safe.
Learn more about Cetyl Alcohol →
Caprylyl Glycol
Deodorant, Hair Conditioning, Skin Conditioning, Emollient
Caprylyl Glycol is the diol that conforms to the formula
Learn more about Caprylyl Glycol →
Phenoxyethanol
Antimicrobial, Preservative
Phenoxyethanol is the aromatic ether alcohol that conforms to the formula:
Learn more about Phenoxyethanol →