SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide and Copper peptides, for hydration and barrier repair.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 28.00 · checked 25 Sept 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
At a Glance
They come out differently on Oil-free; that row is shaded. Tap any answer to see why.
Key Ingredients
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating22
Boosts hydration and relieves dry, tight skin.
Acetyl Heptapeptide-4, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Beta-Glucan, Betaine, Butylene Glycol, Caprylic/Capric Triglyceride, Ceramide NP, Dimethicone, Glycerin, Hyaluronic Acid, Hydrolyzed Collagen, Hydrolyzed Hyaluronic Acid, Inositol, Panthenol, Propanediol, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Squalane, Stearic Acid, Tocopherol
Barrier Repair20
Strengthens and restores the skin's natural barrier.
Bakuchiol, Betaine, C30-45 Alkyl Cetearyl Dimethicone Crosspolymer, Caprylic/Capric Triglyceride, Caprylyl Glycol, Ceramide NP, Cetearyl Alcohol, Cholesterol, Dimethicone, Glycerin, Glyceryl Caprylate, Glyceryl Stearate, Hydrolyzed Collagen, Niacinamide, Palmitic Acid, Panthenol, Squalane, Stearic Acid, Synthetic Wax, Tocopherol
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne6
Can clog pores or trigger breakouts.
Cetearyl Alcohol, Lauric Acid, Myristic Acid, Palmitic Acid, Stearic Acid, Tocopherol
May Worsen Seborrheic Dermatitis18
May feed the yeast involved in seborrheic dermatitis.
Acetyl Heptapeptide-4, Acetyl Hexapeptide-1, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crosspolymer, Ceramide NP, Cetearyl Alcohol, Cetearyl Glucoside, Glyceryl Stearate, Hydrogenated Lecithin, Lauric Acid, Myristic Acid, Palmitic Acid, Polyacrylate Crosspolymer-6, Polyglyceryl-10 Stearate, Polyglyceryl-3 Methylglucose Distearate, Sodium Acetylated Hyaluronate, Stearic Acid
May Worsen Keratosis Pilaris6
May clog follicles or strip skin prone to keratosis pilaris.
Cetearyl Alcohol, Lauric Acid, Myristic Acid, Palmitic Acid, Stearic Acid, Tocopherol
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Skin Conditioning
Emollient
2 / 1
- Fatty alcohol
- Fatty alcohols (Malassezia)
- May Trigger Acne
- May Worsen Keratosis Pilaris
- May Worsen Seborrheic Dermatitis
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Aqua
Solvent
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Squalane
Hair Conditioning, Refatting, Skin Conditioning, Emollient
Squalane is a face oil.
Learn more about Squalane →Dimethicone
Antifoaming, Skin Conditioning, Emollient, Skin Protecting
Dimethicone is a silicone.
Learn more about Dimethicone →Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Palmitic Acid
Emollient, Emulsifying
Palmitic Acid may be plant, synthetic or animal depending on the supplier.
Learn more about Palmitic Acid →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Caprylyl Glycol
Deodorant, Hair Conditioning, Skin Conditioning, Emollient
Caprylyl Glycol is the diol that conforms to the formula
Learn more about Caprylyl Glycol →
Similar Comparisons
Each product against its closest dupes.
- View the comparison
COSRX
The Blue Peptide Bakuchiol Plump Bounce Cream
COSRX
The Retinol 0.3 Cream
- View the comparison
SkinCeuticals
Advanced RGN-6
La Roche-Posay
Toleriane Double Repair Face Moisturizer
- View the comparison
COSRX
The Blue Peptide Bakuchiol Plump Bounce Cream
AESTURA
ATOBARRIER365 HYDRO SOOTHING CREAM (NEW)
- View the comparison
SkinCeuticals
Advanced RGN-6
Rejuran
Triple Radiance Cream