SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide, for barrier repair and smoothing.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 28.00 · checked 28 Sept 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
At a Glance
They come out differently on Fragrance-free and EU-allergen-free; those rows are shaded. Tap any answer to see why.
Key Ingredients
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating18
Boosts hydration and relieves dry, tight skin.
Anhydroxylitol, Bixa Orellana Seed Oil, Butylene Glycol, Caprylic/Capric Triglyceride, Ceramide NP, Dipotassium Glycyrrhizate, Glucose, Glycerin, Helianthus Annuus Seed Oil, Jasminum Officinale Extract, Mannose, Methyl Gluceth-20, Panthenol, Propanediol, Sodium Hyaluronate, Tocopherol, Xylitol, Xylitylglucoside
Barrier Repair29
Strengthens and restores the skin's natural barrier.
Allantoin, Arachidyl Alcohol, Behenyl Alcohol, Bixa Orellana Seed Oil, Camellia Japonica Seed Oil, Caprylic/Capric Triglyceride, Centella Asiatica Extract, Ceramide NP, Cetearyl Alcohol, Cetearyl Olivate, Cetyl Ethylhexanoate, Glycerin, Glyceryl Stearate Citrate, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hippophae Rhamnoides Fruit Oil, Hydrogenated Polydecene, Hydrogenated Polyisobutene, Iris Versicolor Extract, Macadamia Ternifolia Seed Oil, Neopentyl Glycol Diheptanoate, Niacinamide, Oenothera Biennis Oil, Olea Europaea Fruit Oil, Panthenol, Persea Gratissima Oil, Simethicone, Tocopherol, Xylitol
Reduces Irritation5
Eases discomfort and supports skin resilience.
Allantoin, Centella Asiatica Extract, Dipotassium Glycyrrhizate, Jasminum Officinale Extract, Panthenol
Redness Reducing4
Soothes visible redness and calms irritation.
Allantoin, Centella Asiatica Extract, Jasminum Officinale Extract, Niacinamide
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne8
Can clog pores or trigger breakouts.
Cetearyl Alcohol, Glycine Soja Oil, Oenothera Biennis Oil, Olea Europaea Fruit Oil, Persea Gratissima Oil, Prunus Amygdalus Dulcis Oil, Sorbitan Isostearate, Tocopherol
May Worsen Seborrheic Dermatitis22
May feed the yeast involved in seborrheic dermatitis.
Arachidyl Alcohol, Arachidyl Glucoside, Behenyl Alcohol, Bixa Orellana Seed Oil, Camellia Japonica Seed Oil, Ceramide NP, Cetearyl Alcohol, Cetearyl Olivate, Cetyl Ethylhexanoate, Glyceryl Stearate Citrate, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hippophae Rhamnoides Fruit Oil, Macadamia Ternifolia Seed Oil, Oenothera Biennis Oil, Olea Europaea Fruit Oil, Persea Gratissima Oil, Polyglyceryl-3 Distearate, Prunus Amygdalus Dulcis Oil, Sorbitan Isostearate, Sorbitan Olivate, Sorbitan Stearate
May Worsen Keratosis Pilaris8
May clog follicles or strip skin prone to keratosis pilaris.
Cetearyl Alcohol, Glycine Soja Oil, Oenothera Biennis Oil, Olea Europaea Fruit Oil, Persea Gratissima Oil, Prunus Amygdalus Dulcis Oil, Sorbitan Isostearate, Tocopherol
May Worsen Oily Skin10
May increase shine or excess oil.
Bixa Orellana Seed Oil, Camellia Japonica Seed Oil, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hippophae Rhamnoides Fruit Oil, Macadamia Ternifolia Seed Oil, Oenothera Biennis Oil, Olea Europaea Fruit Oil, Persea Gratissima Oil, Prunus Amygdalus Dulcis Oil
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Skin Conditioning
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Emollient
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Skin Conditioning
Skin Conditioning
Emollient
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Glyceryl Stearate Citrate (in both products)
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Glyceryl Stearate Citrate
Skin Conditioning, Emollient, Emulsifying
Glyceryl Stearate Citrate isn't fungal acne safe.
Learn more about Glyceryl Stearate Citrate →Xanthan Gum
Binding, Emulsion Stabilising, Gel Forming, Skin Conditioning, Cleansing, Emulsifying, Viscosity Controlling
Xanthan gum
Learn more about Xanthan Gum →
Similar Comparisons
Each product against its closest dupes.
- View the comparisonNo product image
d'Alba
White Truffle Double Moisture Cream
d'Alba
Piedmont Vita Toning Capsule Cream (Tube)
- View the comparison
SkinCeuticals
Advanced RGN-6
La Roche-Posay
Toleriane Double Repair Face Moisturizer
- View the comparisonNo product image
d'Alba
White Truffle Double Moisture Cream
d'Alba
Vita Toning Capsule Cream
- View the comparison
SkinCeuticals
Advanced RGN-6
Rejuran
Triple Radiance Cream