SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide and Panthenol, for hydration and barrier repair.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
Not recorded · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
Buy at
Retailer links are affiliate links. Buying through one may earn us a commission at no cost to you.
At a Glance
They come out differently on Fragrance-free and EU-allergen-free; those rows are shaded. Tap any answer to see why.
Key Ingredients
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Ceramide3
Skin-identical lipids that hold the barrier together.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating24
Boosts hydration and relieves dry, tight skin.
Butylene Glycol, Caprylic/Capric Triglyceride, Ceramide AP, Ceramide EOP, Ceramide NP, Diglycerin, Erythritol, Glycerin, Helianthus Annuus Seed Oil, Hyaluronic Acid, Hydrolyzed Glycosaminoglycans, Hydrolyzed Hyaluronic Acid, Panthenol, Polyglutamic Acid, Propanediol, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sorbitol, Squalane, Stearic Acid, Streptococcus Thermophilus Ferment, Tocopherol, Vegetable Oil
Barrier Repair23
Strengthens and restores the skin's natural barrier.
Allantoin, Aloe Barbadensis Flower Extract, Caprylic/Capric Triglyceride, Caprylyl Glycol, Ceramide AP, Ceramide EOP, Ceramide NP, Cetearyl Alcohol, Cholesterol, Glycerin, Glyceryl Stearate, Helianthus Annuus Seed Oil, Hydrogenated Poly(C6-14 Olefin), Hydrogenated Polydecene, Macadamia Integrifolia Seed Oil, Niacinamide, Palmitic Acid, Panthenol, Phytosphingosine, Squalane, Stearic Acid, Tocopherol, Vegetable Oil
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne5
Can clog pores or trigger breakouts.
Cetearyl Alcohol, Palmitic Acid, Sorbitan Isostearate, Stearic Acid, Tocopherol
May Worsen Seborrheic Dermatitis24
May feed the yeast involved in seborrheic dermatitis.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C12-20 Alkyl Glucoside, C14-22 Alcohols, Ceramide AP, Ceramide As, Ceramide EOP, Ceramide NP, Ceramide Ns, Cetearyl Alcohol, Chamaecyparis Obtusa Oil, Glyceryl Stearate, Helianthus Annuus Seed Oil, Hydrogenated Lecithin, Hydrogenated Rice Bran Oil, Macadamia Integrifolia Seed Oil, Palmitic Acid, Phytosphingosine, Polyglyceryl-10 Stearate, Potassium Cetyl Phosphate, Sodium Acetylated Hyaluronate, Sorbitan Isostearate, Stearic Acid, Triolein, Vegetable Oil
May Worsen Keratosis Pilaris5
May clog follicles or strip skin prone to keratosis pilaris.
Cetearyl Alcohol, Palmitic Acid, Sorbitan Isostearate, Stearic Acid, Tocopherol
May Worsen Oily Skin6
May increase shine or excess oil.
Chamaecyparis Obtusa Oil, Helianthus Annuus Seed Oil, Hydrogenated Rice Bran Oil, Macadamia Integrifolia Seed Oil, Squalane, Vegetable Oil
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Humectant
Emollient
Macadamia Integrifolia Seed Oil
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Hydrogenated Poly(C6-14 Olefin)
Emollient
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Squalane
Hair Conditioning, Refatting, Skin Conditioning, Emollient
Squalane is a face oil.
Learn more about Squalane →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Caprylyl Glycol
Deodorant, Hair Conditioning, Skin Conditioning, Emollient
Caprylyl Glycol is the diol that conforms to the formula
Learn more about Caprylyl Glycol →Palmitic Acid
Emollient, Emulsifying
Palmitic Acid may be plant, synthetic or animal depending on the supplier.
Learn more about Palmitic Acid →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →
Similar Comparisons
Each product against its closest dupes.
- View the comparison
Goodal
Heartleaf PDRN Hyaluron Cream
Anua
PDRN Hyaluronic Acid 100 Moisturizing Cream
- View the comparison
SkinCeuticals
Advanced RGN-6
La Roche-Posay
Toleriane Double Repair Face Moisturizer
- View the comparison
Goodal
Heartleaf PDRN Hyaluron Cream
Medicube
Hyaluronic Ceramide Moisturizing Jelly Cream
- View the comparison
SkinCeuticals
Advanced RGN-6
Rejuran
Triple Radiance Cream