SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide and Hyaluronic acid, for hydration and barrier repair.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
Not recorded · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
Buy at
Retailer links are affiliate links. Buying through one may earn us a commission at no cost to you.

At a Glance

They come out differently on Silicone-free, Oil-free and Cruelty-free; those rows are shaded. Tap any answer to see why.

Key Ingredients

Centella asiatica (Cica)1
Centella asiatica (cica), used to calm irritation.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.

Benefits

Hydrating16
Boosts hydration and relieves dry, tight skin.
Butylene Glycol, Dimethylsilanol Hyaluronate, Glycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Glyceryl Glucoside, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Jojoba Esters, Panthenol, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate Dimethylsilanol, Tocopherol, Zinc Hydrolyzed Hyaluronate, Zinc PCA
Barrier Repair10
Strengthens and restores the skin's natural barrier.
Allantoin, Centella Asiatica Extract, Glycerin, Isododecane, Isononyl Isononanoate, Jojoba Esters, Niacinamide, Panthenol, Pentaerythrityl Tetraethylhexanoate, Tocopherol
Reduces Irritation6
Eases discomfort and supports skin resilience.
Allantoin, Centella Asiatica Extract, Hamamelis Virginiana Water, Jojoba Esters, Panthenol, Zinc PCA
Redness Reducing5
Soothes visible redness and calms irritation.
Allantoin, Centella Asiatica Extract, Hamamelis Virginiana Water, Jojoba Esters, Niacinamide
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol

Concerns

May Worsen Seborrheic Dermatitis4
May feed the yeast involved in seborrheic dermatitis.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Jojoba Esters, Polyglyceryl-3 Methylglucose Distearate, Sodium Acetylated Hyaluronate
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.

Ingredients Side-by-side

Skin Conditioning
Emollient
Emollient
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Polyglyceryl-3 Methylglucose Distearate
Emulsifying
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
Pentaerythrityl Tetraethylhexanoate
Emollient
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →
Similar Comparisons
Each product against its closest dupes.
- View the comparison

Isntree
Ultra-Low Molecular Hyaluronic Acid Zinc Aqua Cream

Medicube
Hyaluronic Ceramide Moisturizing Jelly Cream
- View the comparison

SkinCeuticals
Advanced RGN-6

La Roche-Posay
Toleriane Double Repair Face Moisturizer
- View the comparison

Isntree
Ultra-Low Molecular Hyaluronic Acid Zinc Aqua Cream

ROUND LAB
Birch Moisturizing Cream
- View the comparison

SkinCeuticals
Advanced RGN-6

Rejuran
Triple Radiance Cream