SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide, for hydration and barrier repair.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 23.00 · checked 8 Oct 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
At a Glance
They come out differently on Fragrance-free, EU-allergen-free and Pore-clogger-free; those rows are shaded. Tap any answer to see why.
Key Ingredients
Fatty alcohol2
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Hyaluronic acid3
Hyaluronic acid and its salts; a humectant that binds water to the skin.
Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating17
Boosts hydration and relieves dry, tight skin.
Butylene Glycol, Butyrospermum Parkii Butter, Caprylic/Capric Triglyceride, Collagen Water, Dimethicone, Glucose, Glycerin, Glyceryl Glucoside, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Propanediol, Simmondsia Chinensis Seed Oil, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Squalane, Stearyl Alcohol
Barrier Repair16
Strengthens and restores the skin's natural barrier.
Arachidyl Alcohol, Behenyl Alcohol, Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Citrus Junos Fruit Oil, Dimethicone, Glycerin, Glyceryl Stearate, Niacinamide, Olea Europaea Fruit Oil, Palmitic Acid, Simmondsia Chinensis Seed Oil, Squalane, Stearyl Alcohol
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne5
Can clog pores or trigger breakouts.
Cetearyl Alcohol, Olea Europaea Fruit Oil, Palmitic Acid, Simmondsia Chinensis Seed Oil, Stearyl Alcohol
May Worsen Seborrheic Dermatitis15
May feed the yeast involved in seborrheic dermatitis.
Arachidyl Alcohol, Arachidyl Glucoside, Behenyl Alcohol, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetearyl Alcohol, Glyceryl Stearate, Hydrogenated Lecithin, Olea Europaea Fruit Oil, Palmitic Acid, Polyglyceryl-10 Laurate, Polyglyceryl-2 Stearate, Simmondsia Chinensis Seed Oil, Sodium Acetylated Hyaluronate, Stearyl Alcohol
May Worsen Keratosis Pilaris5
May clog follicles or strip skin prone to keratosis pilaris.
Cetearyl Alcohol, Olea Europaea Fruit Oil, Palmitic Acid, Simmondsia Chinensis Seed Oil, Stearyl Alcohol
May Worsen Oily Skin4
May increase shine or excess oil.
Butyrospermum Parkii Butter, Olea Europaea Fruit Oil, Simmondsia Chinensis Seed Oil, Squalane
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Skin Conditioning
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Skin Conditioning
Butyrospermum Parkii Butter (in both products)
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
C12-16 Alcohols (in both products)
Emollient
- Fatty alcohols (Malassezia)
- May Worsen Seborrheic Dermatitis
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Butyrospermum Parkii Butter (in both products)
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Butyrospermum Parkii Butter
Skin Conditioning, Viscosity Controlling
Butyrospermum Parkii Butter isn't fungal acne safe.
Learn more about Butyrospermum Parkii Butter →Squalane
Hair Conditioning, Refatting, Skin Conditioning, Emollient
Squalane is a face oil.
Learn more about Squalane →Dimethicone
Antifoaming, Skin Conditioning, Emollient, Skin Protecting
Dimethicone is a silicone.
Learn more about Dimethicone →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →C12-16 Alcohols
Antistatic, Emulsion Stabilising, Hair Conditioning, Emollient, Viscosity Controlling
C12-16 Alcohols isn't fungal acne safe.
Learn more about C12-16 Alcohols →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Palmitic Acid
Emollient, Emulsifying
Palmitic Acid may be plant, synthetic or animal depending on the supplier.
Learn more about Palmitic Acid →Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →
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