SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide and Vitamin E, for barrier repair and hydration.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 32.00 · checked 26 Sept 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
At a Glance
Every check both products could be assessed on comes out the same. Tap any answer to see why.
Key Ingredients
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Vitamin C (L-ascorbic acid)1
L-ascorbic acid, the unesterified form of vitamin C.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating14
Boosts hydration and relieves dry, tight skin.
Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Acetyl Tetrapeptide-5, Butylene Glycol, Caprylic/Capric Triglyceride, Ceramide NP, Dimethicone, Dipotassium Glycyrrhizate, Glycerin, Hyaluronic Acid, Hydrolyzed Collagen, Sorbitol, Stearic Acid, Tocopherol
Barrier Repair18
Strengthens and restores the skin's natural barrier.
Acetyl Tetrapeptide-3, Brassica Campestris Sterols, Caprylic/Capric Triglyceride, Ceramide NP, Cetearyl Alcohol, Cholesterol, Diethylhexyl Syringylidenemalonate, Dimethicone, Glycerin, Glyceryl Stearate, Hydrogenated Polyisobutene, Hydrolyzed Collagen, Lecithin, Macadamia Ternifolia Seed Oil, Niacinamide, Palmitic Acid, Stearic Acid, Tocopherol
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne4
Can clog pores or trigger breakouts.
May Worsen Seborrheic Dermatitis19
May feed the yeast involved in seborrheic dermatitis.
Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Acetyl Tetrapeptide-9, Aluminum/Magnesium Hydroxide Stearate, Ceramide NP, Cetearyl Alcohol, Glyceryl Stearate, Hydrogenated Lecithin, Lecithin, Macadamia Ternifolia Seed Oil, Palmitic Acid, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Polyglyceryl-10 Laurate, Polyglyceryl-3 Methylglucose Distearate, Potassium Cetyl Phosphate, Stearic Acid
May Worsen Keratosis Pilaris4
May clog follicles or strip skin prone to keratosis pilaris.
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Skin Conditioning
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Dimethicone
Antifoaming, Skin Conditioning, Emollient, Skin Protecting
Dimethicone is a silicone.
Learn more about Dimethicone →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Palmitic Acid
Emollient, Emulsifying
Palmitic Acid may be plant, synthetic or animal depending on the supplier.
Learn more about Palmitic Acid →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →Acetyl Tetrapeptide-9
Skin Conditioning
Acetyl Tetrapeptide-9 isn't fungal acne safe.
Learn more about Acetyl Tetrapeptide-9 →
Similar Comparisons
Each product against its closest dupes.
- View the comparison
Medicube
PDRN Collagen Gua Sha Neck Wrinkle Cream
Anua
Collagen Retinol Refining Gua Sha Cream
- View the comparison
SkinCeuticals
Advanced RGN-6
La Roche-Posay
Toleriane Double Repair Face Moisturizer
- View the comparison
Medicube
PDRN Collagen Gua Sha Neck Wrinkle Cream
BIOHEAL BOH
NAD-Prizcell Glow Boost Cream
- View the comparison
SkinCeuticals
Advanced RGN-6
Rejuran
Triple Radiance Cream