SkinCeuticals
Advanced RGN-6A face cream built around Niacinamide and Panthenol, for barrier repair and pollution defence.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 22.40 · checked 26 Sept 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site

At a Glance

They come out differently on Cruelty-free; that row is shaded. Tap any answer to see why.

Key Ingredients

Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.

Benefits

Hydrating11
Boosts hydration and relieves dry, tight skin.
Argania Spinosa Kernel Oil, Butylene Glycol, Ceramide NP, Glycerin, Helianthus Annuus Seed Oil, Panthenol, Polyglutamic Acid, Propanediol, Sodium Hyaluronate, Tocopherol, Trehalose
Barrier Repair17
Strengthens and restores the skin's natural barrier.
Allantoin, Argania Spinosa Kernel Oil, C12-16 Alcohols, Ceramide NP, Cetearyl Olivate, Cholesterol, Eriobotrya Japonica Leaf Extract, Glycerin, Helianthus Annuus Seed Oil, Lecithin, Niacinamide, Octyldodecanol, Palmitic Acid, Panthenol, Sesamum Indicum Seed Oil, Sh-Oligopeptide-2, Tocopherol
Reduces Irritation6
Eases discomfort and supports skin resilience.
Allantoin, Asiaticoside, Bisabolol, Centella Asiatica Leaf Extract, Madecassoside, Panthenol
Redness Reducing6
Soothes visible redness and calms irritation.
Allantoin, Asiaticoside, Bisabolol, Centella Asiatica Leaf Extract, Madecassoside, Niacinamide
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol

Concerns

May Trigger Acne4
Can clog pores or trigger breakouts.
Palmitic Acid, Sesamum Indicum Seed Oil, Sorbitan Isostearate, Tocopherol
May Worsen Seborrheic Dermatitis17
May feed the yeast involved in seborrheic dermatitis.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Argania Spinosa Kernel Oil, C12-16 Alcohols, Ceramide NP, Cetearyl Olivate, Dilauryl Thiodipropionate, Helianthus Annuus Seed Oil, Hydrogenated Lecithin, Lecithin, Octyldodecanol, Palmitic Acid, Phosphatidylcholine, Polyglyceryl-10 Behenate/Eicosadioate, Polyglyceryl-10 Laurate, Sesamum Indicum Seed Oil, Sorbitan Isostearate, Sorbitan Olivate
May Worsen Keratosis Pilaris4
May clog follicles or strip skin prone to keratosis pilaris.
Palmitic Acid, Sesamum Indicum Seed Oil, Sorbitan Isostearate, Tocopherol
May Worsen Oily Skin3
May increase shine or excess oil.
Argania Spinosa Kernel Oil, Helianthus Annuus Seed Oil, Sesamum Indicum Seed Oil
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.

Ingredients Side-by-side

Skin Conditioning
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
0 / 0
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Skin Conditioning
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide (in both products)
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
C12-16 Alcohols (in both products)
Emollient
- Fatty alcohols (Malassezia)
- May Worsen Seborrheic Dermatitis
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Niacinamide
Smoothing
Niacinamide is niacinamide.
Learn more about Niacinamide →Xanthan Gum
Binding, Emulsion Stabilising, Gel Forming, Skin Conditioning, Cleansing, Emulsifying, Viscosity Controlling
Xanthan gum
Learn more about Xanthan Gum →C12-16 Alcohols
Antistatic, Emulsion Stabilising, Hair Conditioning, Emollient, Viscosity Controlling
C12-16 Alcohols isn't fungal acne safe.
Learn more about C12-16 Alcohols →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Adenosine
Skin Conditioning
6-Amino-9-beta-D-ribofuranosyl-9H-purine
Learn more about Adenosine →Palmitic Acid
Emollient, Emulsifying
Palmitic Acid may be plant, synthetic or animal depending on the supplier.
Learn more about Palmitic Acid →Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →
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