SkinCeuticals Advanced RGN-6 vs SkinCeuticals Retinol 0.3

SkinCeuticals

SkinCeuticals

A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.

A face cream built around Retinoid, for smoothing and barrier repair.

Face cream

29 ingredients

22 ingredients

Brand price

USD 195.00 · checked 28 Sept 2026 · brand's site

Brand price

USD 80.00 · checked 28 Sept 2026 · brand's site

No retailer listed yet

At a Glance

They come out differently on Alcohol-free and Oil-free; those rows are shaded. Tap any answer to see why.

Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Cetyl Alcohol
Face oil1
An oil formulated to be used on the face.
Squalane
Vitamin E1
Tocopherols — fat-soluble antioxidants.
Tocopherol
AHA1
Alpha hydroxy acids — water-soluble chemical exfoliants.
Citric Acid

Polysorbates (Tween emulsifiers)1
Polysorbate (Tween) emulsifiers.
Polysorbate 20
Retinoid1
Vitamin A derivatives that speed cell turnover.
Retinol
AHA1
Alpha hydroxy acids — water-soluble chemical exfoliants.
Citric Acid

Hydrating3
Boosts hydration and relieves dry, tight skin.
Dimethicone, Dimethiconol, Propanediol
Barrier Repair5
Strengthens and restores the skin's natural barrier.
Caprylyl Glycol, Cetearyl Ethylhexanoate, Dimethicone, Dimethiconol, Isopropyl Myristate
Reduces Irritation1
Eases discomfort and supports skin resilience.
Bisabolol
Redness Reducing1
Soothes visible redness and calms irritation.
Bisabolol

May Trigger Acne3
Can clog pores or trigger breakouts.
Cetyl Alcohol, Palmitic Acid, Tocopherol
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Cetyl Alcohol, Palmitic Acid, Tocopherol
May Worsen Oily Skin2
May increase shine or excess oil.
Butyrospermum Parkii Butter, Squalane

May Trigger Acne1
Can clog pores or trigger breakouts.
Isopropyl Myristate
May Worsen Seborrheic Dermatitis4
May feed the yeast involved in seborrheic dermatitis.
Cetearyl Ethylhexanoate, Hydrogenated Lecithin, Isopropyl Myristate, Polysorbate 20
May Worsen Keratosis Pilaris1
May clog follicles or strip skin prone to keratosis pilaris.
Isopropyl Myristate
May Worsen Irritation2
May cause stinging, redness or sensitivity.
Alcohol Denat., Isopropyl Myristate

Show highlights for:

Aqua (in both products)
Solvent
0 / —
Glycerin
Humectant
0 / 0
- Possibly animal-derived
- Hydrating
Ethyl Oleate
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Niacinamide
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Squalane
Emollient
1 / 0
- Face oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
C12-16 Alcohols
Emollient
- Fatty alcohols (Malassezia)
- May Worsen Seborrheic Dermatitis
Glyceryl Stearate Citrate
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Butyrospermum Parkii Butter
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Maltodextrin
Skin Conditioning
0-1 / —
Ammonium Polyacryloyldimethyl Taurate (in both products)
Emulsion Stabilising

Aqua (in both products)
Solvent
0 / —
Propanediol
Viscosity Controlling
0-1 / —
- Hydrating
Dimethicone (in both products)
Emollient
1 / 0
- Silicones
- Barrier Repair
- Hydrating
- Smoothing
Cetearyl Ethylhexanoate
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Alcohol Denat.
Fragrance
0 / —
- Denatured alcohol
- May Worsen Dryness
- May Worsen Eczema
- May Worsen Irritation
- May Worsen Rosacea
Dipropylene Glycol
Perfuming
0-1 / —
Ammonium Polyacryloyldimethyl Taurate (in both products)
Emulsion Stabilising
Hydrogenated Lecithin (in both products)
Emulsifying
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Allyl Methacrylates Crosspolymer
Emulsion Stabilising
Phenoxyethanol (in both products)
Preservative
0 / —

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Aqua
Solvent
Water
Learn more about Aqua →
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising, Viscosity Controlling
1-Propanesulfonic acid, 2-methyl-2-[(1-oxo-2-propenyl)amino]-, monoammonium salt, homopolymer
Learn more about Ammonium Polyacryloyldimethyl Taurate →
Phenoxyethanol
Antimicrobial, Preservative
Phenoxyethanol is the aromatic ether alcohol that conforms to the formula:
Learn more about Phenoxyethanol →
Dimethicone
Antifoaming, Skin Conditioning, Emollient, Skin Protecting
Dimethicone is a silicone.
Learn more about Dimethicone →
Hydrogenated Lecithin
Skin Conditioning, Emulsifying
Hydrogenated Lecithin isn't fungal acne safe.
Learn more about Hydrogenated Lecithin →
Caprylyl Glycol
Deodorant, Hair Conditioning, Skin Conditioning, Emollient
Caprylyl Glycol is the diol that conforms to the formula
Learn more about Caprylyl Glycol →
Citric Acid
Buffering, Chelating, Fragrance
Citric Acid is an AHA.
Learn more about Citric Acid →