SkinCeuticals
Advanced RGN-6A face cream built around Vitamin E and BHA, for barrier repair and smoothing.
A face cream built around Niacinamide and Vitamin E, for barrier repair and smoothing.
Brand price
USD 260.00 · checked 26 Sept 2026 · brand's site
Brand price
USD 195.00 · checked 28 Sept 2026 · brand's site
At a Glance
They come out differently on Fragrance-free and EU-allergen-free; those rows are shaded. Tap any answer to see why.
Key Ingredients
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Fatty alcohol1
Waxy fatty alcohols used as emollients and thickeners; unrelated to drying alcohol.
Benefits
Hydrating19
Boosts hydration and relieves dry, tight skin.
Acetyl Glucosamine, Acetyl Heptapeptide-4, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Beta-Glucan, Butylene Glycol, Dimethicone, Dimethiconol, Glycerin, Helianthus Annuus Seed Oil, Jojoba Esters, Mannitol, Propanediol, Propylene Glycol, Sodium Hyaluronate, Squalane, Stearic Acid, Tocopherol, Trehalose
Barrier Repair30
Strengthens and restores the skin's natural barrier.
Caprylyl Glycol, Cetearyl Alcohol, Copernicia Cerifera Wax, Dimethicone, Dimethiconol, Glycerin, Glyceryl Stearate, Glycine Soja Oil, Glycine Soja Sterols, Helianthus Annuus Seed Oil, Hexyl Laurate, Hydrogenated Vegetable Glycerides Citrate, Hydrogenated Vegetable Oil, Isostearyl Alcohol, Jojoba Esters, Lecithin, Limnanthes Alba Seed Oil, Mangifera Indica Seed Butter, Octyldodecyl Myristate, Palmitic Acid, Panax Ginseng Root Extract, Pantethine, Persea Gratissima Oil, Phytosphingosine, Phytosteryl Isostearyl Dimer Dilinoleate, Propylene Glycol, Squalane, Stearic Acid, Tocopherol, Tocopheryl Linoleate
Hydrating6
Boosts hydration and relieves dry, tight skin.
Butyrospermum Parkii Butter, Dimethicone, Ectoin, Glycerin, Squalane, Tocopherol
Barrier Repair13
Strengthens and restores the skin's natural barrier.
Butyrospermum Parkii Butter, C12-16 Alcohols, Caprylyl Glycol, Cetyl Alcohol, Dimethicone, Eperua Falcata Bark Extract, Ethyl Oleate, Glycerin, Glyceryl Stearate Citrate, Niacinamide, Palmitic Acid, Squalane, Tocopherol
Concerns
May Trigger Acne9
Can clog pores or trigger breakouts.
Ascorbyl Palmitate, Cetearyl Alcohol, Glycine Soja Oil, Hydrogenated Vegetable Oil, Palmitic Acid, Persea Gratissima Oil, Sorbitan Isostearate, Stearic Acid, Tocopherol
May Worsen Seborrheic Dermatitis33
May feed the yeast involved in seborrheic dermatitis.
Acetyl Glucosamine, Acetyl Heptapeptide-4, Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Acetyl Tetrapeptide-11, Ascorbyl Palmitate, Cetearyl Alcohol, Copernicia Cerifera Wax, Glyceryl Stearate, Glycine Soja Oil, Helianthus Annuus Seed Oil, Hexyl Laurate, Hydrogenated Vegetable Glycerides Citrate, Hydrogenated Vegetable Oil, Isostearyl Alcohol, Jojoba Esters, Lauryl Peg/Ppg-18/18 Methicone, Lecithin, Limnanthes Alba Seed Oil, Mangifera Indica Seed Butter, Octyldodecyl Myristate, Palmitic Acid, PEG-100 Stearate, PEG-30 Dipolyhydroxystearate, PEG-40 Stearate, Persea Gratissima Oil, Phytosphingosine, Phytosteryl Isostearyl Dimer Dilinoleate, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Polysorbate 20, Sorbitan Isostearate, Stearic Acid, Tocopheryl Linoleate
May Worsen Keratosis Pilaris9
May clog follicles or strip skin prone to keratosis pilaris.
Ascorbyl Palmitate, Cetearyl Alcohol, Glycine Soja Oil, Hydrogenated Vegetable Oil, Palmitic Acid, Persea Gratissima Oil, Sorbitan Isostearate, Stearic Acid, Tocopherol
May Worsen Oily Skin7
May increase shine or excess oil.
Glycine Soja Oil, Helianthus Annuus Seed Oil, Hydrogenated Vegetable Oil, Limnanthes Alba Seed Oil, Mangifera Indica Seed Butter, Persea Gratissima Oil, Squalane
May Worsen Seborrheic Dermatitis9
May feed the yeast involved in seborrheic dermatitis.
2-Oleamido-1,3-Octadecanediol, Acetyl Tetrapeptide-9, Butyrospermum Parkii Butter, C12-16 Alcohols, Cetyl Alcohol, Ethyl Oleate, Glyceryl Stearate Citrate, Hydrogenated Lecithin, Palmitic Acid
May Worsen Keratosis Pilaris3
May clog follicles or strip skin prone to keratosis pilaris.
Ingredients Side-by-side
Skin Conditioning
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Emollient
1 / 0
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- Possibly animal-derived
- May Worsen Seborrheic Dermatitis
Phytosteryl Isostearyl Dimer Dilinoleate
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Smoothing
0 / —
- Niacinamide
- Acne Fighting
- Barrier Repair
- Brightening
- Dark Spots
- Even Tone
- Oil Control
- Pore Refining
- Redness Reducing
Emollient
- Fatty esters (glyceryl stearate, PEG-100 stearate)
- May Worsen Seborrheic Dermatitis
Skin Conditioning
- Plant oils and butters (coconut, olive, shea)
- Plant or mineral oil
- Barrier Repair
- Hydrating
- May Worsen Oily Skin
- May Worsen Seborrheic Dermatitis
Ammonium Polyacryloyldimethyl Taurate
Emulsion Stabilising
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Glycerin
Denaturant, Fragrance, Hair Conditioning, Humectant, Oral Care, Perfuming, Humectant, Skin Protecting, Solvent, Viscosity Controlling
Glycerin may be plant, synthetic or animal depending on the supplier.
Learn more about Glycerin →Squalane
Hair Conditioning, Refatting, Skin Conditioning, Emollient
Squalane is a face oil.
Learn more about Squalane →Dimethicone
Antifoaming, Skin Conditioning, Emollient, Skin Protecting
Dimethicone is a silicone.
Learn more about Dimethicone →Palmitic Acid
Emollient, Emulsifying
Palmitic Acid may be plant, synthetic or animal depending on the supplier.
Learn more about Palmitic Acid →Phenoxyethanol
Antimicrobial, Preservative
Phenoxyethanol is the aromatic ether alcohol that conforms to the formula:
Learn more about Phenoxyethanol →Tocopherol
Antioxidant, Fragrance, Skin Conditioning, Occlusive
Tocopherol is vitamin E.
Learn more about Tocopherol →Ethylhexylglycerin
Deodorant, Skin Conditioning
Ethylhexylglycerin is the organic compound that conforms to the formula
Learn more about Ethylhexylglycerin →Caprylyl Glycol
Deodorant, Hair Conditioning, Skin Conditioning, Emollient
Caprylyl Glycol is the diol that conforms to the formula
Learn more about Caprylyl Glycol →Sodium Hydroxide
Buffering, Denaturant
Sodium hydroxide
Learn more about Sodium Hydroxide →
Similar Comparisons
Each product against its closest dupes.
- View the comparison
Sulwhasoo
Concentrated Ginseng Rejuvenating Cream Rich
Sulwhasoo
The Ultimate S Cream Rich
- View the comparison
SkinCeuticals
Advanced RGN-6
La Roche-Posay
Toleriane Double Repair Face Moisturizer
- View the comparison
Sulwhasoo
Concentrated Ginseng Rejuvenating Cream Rich
Sulwhasoo
Essential Revitalizing Emulsion EX
- View the comparison
SkinCeuticals
Advanced RGN-6
Rejuran
Triple Radiance Cream